Community genetics approaches in the prevention of beta-thalassemia: towards achieving ‘Zero beta-thalassemia’ status in India

THE SPECTRUM OF BETA – THALASSEMIA MUTATIONS IN IRAN

Endocrine Disorders in Beta thalassemia Major Patients

Background Thalassemia is the most common hereditary disorder worldwide. The patient's’ survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity on various organs including endocrine glands. The study aimed to investigate endocrine disorders in patients with Beta-thalassemia major in the Southern Khorasan province, Iran. Materials and Methods In this des...

Prevalence of HCVAb and HBsAg in Patients with Beta-thalassemia Major in Amirkola Thalassemia Center

Background and purpose: Beta-thalassemia major is a genetic disorder with known globin defect that leads to chronic hemolytic anemia. Due to the need for recurrent blood transfusion, the risk of infectious diseases such as hepatitis is higher in these patients. Materials and methods: This cross-sectional study recruited 518 patients with thalassemia major in Amirkola Thalassemia Center, 2013-2...

A Search for Beta Thalassemia Trait in India

remaining 161 cases with an HbA2 level ≤3.5% constituted the non-BTT group. In the BTT group 3 cases had concomitant iron deficiency. In the non-BTT group 120 cases had a serum ferritin level <15 ng/mL and were diagnosed as IDA; of the remaining 41cases, 12 had associated chronic illness indicative of ACD (anemia of chronic disease) and in the other 29 the cause of microcytosis could not be ide...

Oxidative stress and antioxidant status in beta-thalassemia heterozygotes

BACKGROUND Several studies have evaluated the oxidant and antioxidant status of thalassemia patients but most focused mainly on the severe and intermediate states of the disease. Moreover, the oxidative status has not been evaluated for the different beta-thalassemia mutations. OBJECTIVE To evaluate lipid peroxidation and Trolox equivalent antioxidant capacity in relation to serum iron and fe...